3FLS

P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

Summary for 3FLS

• Entry DOI: 10.2210/pdb3fls/pdb
• Related: 3FLN 3FLQ 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK
• Descriptor: Mitogen-activated protein kinase 14, 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1R)-1-methyl-2-(methylsulfonyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
• Functional Keywords: p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43173.14

Authors

Kuglstatter, A.,Ghate, M. (deposition date: 2008-12-19, release date: 2009-12-22, Last modification date: 2024-02-21)

• Primary citation: Soth, M.,Kuglstatter, A.,Goldstein, D.; The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)