3FLQ

P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin

3FLQ の概要

• エントリーDOI: 10.2210/pdb3flq/pdb
• 関連するPDBエントリー: 3FLN 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK
• 分子名称: Mitogen-activated protein kinase 14, 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1S)-1-methyl-2-(methylsulfonyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
• 機能のキーワード: p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43173.14

構造登録者

Kuglstatter, A.,Knapp, M. (登録日: 2008-12-19, 公開日: 2009-12-22, 最終更新日: 2024-02-21)

• 主引用文献: Soth, M.,Kuglstatter, A.,Goldstein, D.; The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase; To be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)