3FI2

Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451

Summary for 3FI2

Entry DOI	10.2210/pdb3fi2/pdb
Related	3FI3
Descriptor	Mitogen-activated protein kinase 10, 3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	jnk3, protein-inhibitor complex, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P53779
Total number of polymer chains	1
Total formula weight	41314.92
Authors	Habel, J.E. (deposition date: 2008-12-10, release date: 2009-03-03, Last modification date: 2023-09-06)
Primary citation	Kamenecka, T.,Habel, J.,Duckett, D.,Chen, W.,Ling, Y.Y.,Frackowiak, B.,Jiang, R.,Shin, Y.,Song, X.,LoGrasso, P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J.Biol.Chem., 284:12853-12861, 2009 Cited by PubMed: 19261605 DOI: 10.1074/jbc.M809430200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation