3FH8

Leukotriene A4 Hydrolase complexed with inhibitor 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine.

3FH8 の概要

• エントリーDOI: 10.2210/pdb3fh8/pdb
• 関連するPDBエントリー: 3FH5 3FH7 3FHE
• 分子名称: Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total)
• 機能のキーワード: lta4h, leukotriene a4, leukotriene b4 biosynthesis, peptidase, hydrolase-hydrolase inhibitor complex, structure based drug design, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 70358.02

構造登録者

Mamat, B.,Davies, D.R. (登録日: 2008-12-09, 公開日: 2010-01-05, 最終更新日: 2023-09-06)

• 主引用文献: Sandanayaka, V.,Mamat, B.,Mishra, R.K.,Winger, J.,Krohn, M.,Zhou, L.M.,Keyvan, M.,Enache, L.,Sullins, D.,Onua, E.,Zhang, J.,Halldorsdottir, G.,Sigthorsdottir, H.,Thorlaksdottir, A.,Sigthorsson, G.,Thorsteinnsdottir, M.,Davies, D.R.,Stewart, L.J.,Zembower, D.E.,Andresson, T.,Kiselyov, A.S.,Singh, J.,Gurney, M.E.; Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.; J.Med.Chem., 53:573-585, 2010; PubMed: 19950900; DOI: 10.1021/jm900838g

実験手法

X-RAY DIFFRACTION (1.67 Å)