3FCO
Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor
3FCO の概要
エントリーDOI | 10.2210/pdb3fco/pdb |
分子名称 | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... (4 entities in total) |
機能のキーワード | oxidoreductase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 65983.48 |
構造登録者 | |
主引用文献 | McMinn, D.L.,Rew, Y.,Sudom, A.,Caille, S.,Degraffenreid, M.,He, X.,Hungate, R.,Jiang, B.,Jaen, J.,Julian, L.D.,Kaizerman, J.,Novak, P.,Sun, D.,Tu, H.,Ursu, S.,Walker, N.P.,Yan, X.,Ye, Q.,Wang, Z.,Powers, J.P. Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 19:1446-1450, 2009 Cited by PubMed: 19185488DOI: 10.1016/j.bmcl.2009.01.026 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.65 Å) |
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