3F9F
Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 6.0
Summary for 3F9F
Entry DOI | 10.2210/pdb3f9f/pdb |
Related | 3F9E 3F9G 3F9H |
Descriptor | 3C-like proteinase (2 entities in total) |
Functional Keywords | protease, cytoplasm, hydrolase, membrane, metal-binding, ribosomal frameshifting, rna-binding, thiol protease, transmembrane, zinc, zinc-finger |
Biological source | SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8 |
Total number of polymer chains | 2 |
Total formula weight | 67889.34 |
Authors | |
Primary citation | Hu, T.,Zhang, Y.,Li, L.,Wang, K.,Chen, S.,Chen, J.,Ding, J.,Jiang, H.,Shen, X. Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure. Virology, 388:324-334, 2009 Cited by PubMed: 19409595DOI: 10.1016/j.virol.2009.03.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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