3F9F

Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 6.0

3F9F の概要

• エントリーDOI: 10.2210/pdb3f9f/pdb
• 関連するPDBエントリー: 3F9E 3F9G 3F9H
• 分子名称: 3C-like proteinase (2 entities in total)
• 機能のキーワード: protease, cytoplasm, hydrolase, membrane, metal-binding, ribosomal frameshifting, rna-binding, thiol protease, transmembrane, zinc, zinc-finger
• 由来する生物種: SARS coronavirus (SARS-CoV)
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67889.34

構造登録者

Hu, T.,Li, L.,Jiang, H.,Shen, X. (登録日: 2008-11-13, 公開日: 2009-09-29, 最終更新日: 2023-12-27)

• 主引用文献: Hu, T.,Zhang, Y.,Li, L.,Wang, K.,Chen, S.,Chen, J.,Ding, J.,Jiang, H.,Shen, X.; Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.; Virology, 388:324-334, 2009; PubMed: 19409595; DOI: 10.1016/j.virol.2009.03.034

実験手法

X-RAY DIFFRACTION (2.3 Å)