3F8E

Coumarins are a novel class of suicide carbonic anhydrase inhibitors

3F8E の概要

• エントリーDOI: 10.2210/pdb3f8e/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitors, disease mutation, lyase, metal-binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30158.09

構造登録者

Temperini, C.,Maresca, A.,Scozzafava, A.,Supuran, C.T. (登録日: 2008-11-12, 公開日: 2009-10-06, 最終更新日: 2023-11-01)

• 主引用文献: Maresca, A.,Temperini, C.,Vu, H.,Pham, N.B.,Poulsen, S.-A.,Scozzafava, A.,Quinn, R.J.,Supuran, C.T.; Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors; J.Am.Chem.Soc., 131:3057-3062, 2009; PubMed: 19206230; DOI: 10.1021/ja809683v

実験手法

X-RAY DIFFRACTION (2 Å)