3F88

glycogen synthase Kinase 3beta inhibitor complex

3F88 の概要

• エントリーDOI: 10.2210/pdb3f88/pdb
• 関連するPDBエントリー: 3F7Z
• 分子名称: Glycogen synthase kinase-3 beta, 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione, 3-methylbenzonitrile, ... (4 entities in total)
• 機能のキーワード: enzyme, protein kinase, inhibitor, alternative splicing, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P49841
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80362.28

構造登録者

Mol, C.D.,Dougan, D.R. (登録日: 2008-11-11, 公開日: 2009-03-10, 最終更新日: 2023-12-27)

• 主引用文献: Saitoh, M.,Kunitomo, J.,Kimura, E.,Hayase, Y.,Kobayashi, H.,Uchiyama, N.,Kawamoto, T.,Tanaka, T.,Mol, C.D.,Dougan, D.R.,Textor, G.S.,Snell, G.P.,Itoh, F.; Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.; Bioorg.Med.Chem., 17:2017-2029, 2009; PubMed: 19200745; DOI: 10.1016/j.bmc.2009.01.019

実験手法

X-RAY DIFFRACTION (2.6 Å)