3F87

An alpha/beta-Peptide Helix Bundle with a Pure beta-Amino Acid Core and a Distinctive Quarternary Structure: GCN4pLI derivative with beta residues at a and d heptad positions - higher symmetry crystal

3F87 の概要

• エントリーDOI: 10.2210/pdb3f87/pdb
• 関連するPDBエントリー: 1GCL 2OXJ 2OXK 2ZTA
• 分子名称: GCN4pLI-betaAD, IODIDE ION (3 entities in total)
• 機能のキーワード: alpha/beta-peptide, helix bundle, foldamer, gcn4 derivative, unknown function
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 17990.53

構造登録者

Giuliano, M.W.,Horne, W.S.,Gellman, S.H. (登録日: 2008-11-11, 公開日: 2009-07-21, 最終更新日: 2023-11-15)

主引用文献

Giuliano, M.W.,Horne, W.S.,Gellman, S.H.
An alpha/beta-peptide helix bundle with a pure beta3-amino acid core and a distinctive quaternary structure.
J.Am.Chem.Soc., 131:9860-9861, 2009

PubMed Abstract: Helix bundles are among the most widely studied tertiary and quaternary structural motifs in proteins. Here we present the crystal structure of an alpha/beta-peptide foldamer that adopts a tetrameric helix-bundle quaternary structure with a hydrophobic core composed solely of beta-amino acids. The structure displays features that are unprecedented among all known helix bundles composed of either alpha-peptides or peptidic foldamers. The tetramer is characterized by an asymmetry of interaction between neighboring helices, and the side-chain packing within the hydrophobic core differs fundamentally from the knobs-into-holes arrangement typical of most helix bundles.

PubMed: 19580264
DOI: 10.1021/ja8099294

実験手法

X-RAY DIFFRACTION (2.4 Å)