3F80

(S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Resolution 1.60 A.

3F80 の概要

• エントリーDOI: 10.2210/pdb3f80/pdb
• 分子名称: Arginase-1, MANGANESE (II) ION, 6-nitro-L-norleucine, ... (4 entities in total)
• 機能のキーワード: nitronium group coordination, surface plasmon resonance, alternative splicing, arginine metabolism, cytoplasm, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, polymorphism, urea cycle
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P05089
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70131.85

構造登録者

Di Costanzo, L.,Christianson, D.W. (登録日: 2008-11-10, 公開日: 2008-12-02, 最終更新日: 2023-09-06)

• 主引用文献: Zakharian, T.Y.,Di Costanzo, L.,Christianson, D.W.; (S)-2-Amino-6-nitrohexanoic Acid Binds to Human Arginase I through Multiple Nitro-Metal Coordination Interactions in the Binuclear Manganese Cluster.; J.Am.Chem.Soc., 130:17254-17255, 2008; PubMed: 19032027; DOI: 10.1021/ja807702q

実験手法

X-RAY DIFFRACTION (1.6 Å)