3F4M

Crystal structure of TIPE2

Summary for 3F4M

• Entry DOI: 10.2210/pdb3f4m/pdb
• Descriptor: Tumor necrosis factor, alpha-induced protein 8-like protein 2, CHLORIDE ION (3 entities in total)
• Functional Keywords: tipe2, immune homeostasis, tnfaip8, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 18154.28

Authors

Zhang, X.,Wang, J.,Shi, Y. (deposition date: 2008-11-01, release date: 2009-03-17, Last modification date: 2023-12-27)

Primary citation

Zhang, X.,Wang, J.,Fan, C.,Li, H.,Sun, H.,Gong, S.,Chen, Y.H.,Shi, Y.
Crystal structure of TIPE2 provides insights into immune homeostasis
Nat.Struct.Mol.Biol., 16:89-90, 2009

PubMed Abstract: TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.

PubMed: 19079267
DOI: 10.1038/nsmb.1522

Experimental method

X-RAY DIFFRACTION (1.696 Å)