3F2A

Crystal structure of human Pim-1 in complex with DAPPA

3F2A の概要

• エントリーDOI: 10.2210/pdb3f2a/pdb
• 分子名称: Proto-oncogene serine/threonine-protein kinase Pim-1, (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: potein kinase fold, alternative initiation, atp-binding, cell membrane, cytoplasm, kinase, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34694.59

構造登録者

Qian, K. (登録日: 2008-10-29, 公開日: 2009-03-10, 最終更新日: 2024-10-16)

• 主引用文献: Qian, K.,Wang, L.,Cywin, C.L.,Farmer, B.T.,Hickey, E.,Homon, C.,Jakes, S.,Kashem, M.A.,Lee, G.,Leonard, S.,Li, J.,Magboo, R.,Mao, W.,Pack, E.,Peng, C.,Prokopowicz, A.,Welzel, M.,Wolak, J.,Morwick, T.; Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.; J.Med.Chem., 52:1814-1827, 2009; PubMed: 19256503; DOI: 10.1021/jm801242y

実験手法

X-RAY DIFFRACTION (1.9 Å)