3F0T

Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

3F0T の概要

• エントリーDOI: 10.2210/pdb3f0t/pdb
• 関連するPDBエントリー: 1E2H 1E2P
• 分子名称: Thymidine kinase, SULFATE ION, N-Methyl-6-(1,3-dihydroxy-isobutyl)thymine, ... (4 entities in total)
• 機能のキーワード: transferase, thymidine kinase, dna-synthesis, pet tracer, atp-binding, dna synthesis, early protein, nucleotide-binding
• 由来する生物種: Herpes simplex virus (type 1 / strain 17) (virus)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72849.40

構造登録者

Pernot, L.,Perozzo, R.,Westermaier, Y.,Martic, M.,Ametamey, S.,Scapozza, L. (登録日: 2008-10-26, 公開日: 2009-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Martic, M.,Pernot, L.,Westermaier, Y.,Perozzo, R.,Kraljevic, T.G.,Kristafor, S.,Raic-Malic, S.,Scapozza, L.,Ametamey, S.; Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.; Nucleosides Nucleotides Nucleic Acids, 30:293-315, 2011; PubMed: 21623543; DOI: 10.1080/15257770.2011.581258

実験手法

X-RAY DIFFRACTION (2 Å)