3EZV
CDK-2 with indazole inhibitor 9 bound at its active site
Summary for 3EZV
Entry DOI | 10.2210/pdb3ezv/pdb |
Related | 3EZR |
Descriptor | Cell division protein kinase 2, 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline (3 entities in total) |
Functional Keywords | kinase, pkc, protein kinase, inhibitor, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34544.13 |
Authors | Kiefer, J.R.,Day, J.E.,Caspers, N.L.,Mathis, K.J.,Kretzmer, K.K.,Weinberg, R.A.,Reitz, B.A.,Stegeman, R.A.,Trujillo, J.I.,Huang, W.,Thorarensen, A.,Xing, L.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X. (deposition date: 2008-10-23, release date: 2009-02-03, Last modification date: 2023-12-27) |
Primary citation | Trujillo, J.I.,Kiefer, J.R.,Huang, W.,Thorarensen, A.,Xing, L.,Caspers, N.L.,Day, J.E.,Mathis, K.J.,Kretzmer, K.K.,Reitz, B.A.,Weinberg, R.A.,Stegeman, R.A.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X. 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor Bioorg.Med.Chem.Lett., 19:908-911, 2009 Cited by PubMed: 19097791DOI: 10.1016/j.bmcl.2008.11.105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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