3EZV

CDK-2 with indazole inhibitor 9 bound at its active site

3EZV の概要

• エントリーDOI: 10.2210/pdb3ezv/pdb
• 関連するPDBエントリー: 3EZR
• 分子名称: Cell division protein kinase 2, 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline (3 entities in total)
• 機能のキーワード: kinase, pkc, protein kinase, inhibitor, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34544.13

構造登録者

Kiefer, J.R.,Day, J.E.,Caspers, N.L.,Mathis, K.J.,Kretzmer, K.K.,Weinberg, R.A.,Reitz, B.A.,Stegeman, R.A.,Trujillo, J.I.,Huang, W.,Thorarensen, A.,Xing, L.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X. (登録日: 2008-10-23, 公開日: 2009-02-03, 最終更新日: 2023-12-27)

• 主引用文献: Trujillo, J.I.,Kiefer, J.R.,Huang, W.,Thorarensen, A.,Xing, L.,Caspers, N.L.,Day, J.E.,Mathis, K.J.,Kretzmer, K.K.,Reitz, B.A.,Weinberg, R.A.,Stegeman, R.A.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X.; 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor; Bioorg.Med.Chem.Lett., 19:908-911, 2009; PubMed: 19097791; DOI: 10.1016/j.bmcl.2008.11.105

実験手法

X-RAY DIFFRACTION (1.99 Å)