3ET6

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

3ET6 の概要

• エントリーDOI: 10.2210/pdb3et6/pdb
• 分子名称: Soluble guanylyl cyclase beta, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: guanylate cyclase, guanylyl cyclase, dimethylarsenic, lyase, membrane, transmembrane
• 由来する生物種: Chlamydomonas reinhardtii; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43473.80

構造登録者

Winger, J.A.,Derbyshire, E.R.,Lamers, M.H.,Marletta, M.A.,Kuriyan, J. (登録日: 2008-10-07, 公開日: 2008-10-14, 最終更新日: 2024-11-20)

主引用文献

Winger, J.A.,Derbyshire, E.R.,Lamers, M.H.,Marletta, M.A.,Kuriyan, J.
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.
Bmc Struct.Biol., 8:42-42, 2008

PubMed Abstract: Soluble guanylate cyclases generate cyclic GMP when bound to nitric oxide, thereby linking nitric oxide levels to the control of processes such as vascular homeostasis and neurotransmission. The guanylate cyclase catalytic module, for which no structure has been determined at present, is a class III nucleotide cyclase domain that is also found in mammalian membrane-bound guanylate and adenylate cyclases.

PubMed: 18842118
DOI: 10.1186/1472-6807-8-42

実験手法

X-RAY DIFFRACTION (2.55 Å)