3EQP
Crystal Structure of Ack1 with compound T95
Summary for 3EQP
Entry DOI | 10.2210/pdb3eqp/pdb |
Related | 3EQR |
Descriptor | Activated CDC42 kinase 1, N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-({4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}amino)pyrimidine-5-carboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | ack1, alternative splicing, atp-binding, cell membrane, kinase, magnesium, membrane, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane: Q07912 |
Total number of polymer chains | 2 |
Total formula weight | 64277.63 |
Authors | Liu, J.,Wang, Z.,Walker, N.P.C. (deposition date: 2008-10-01, release date: 2008-12-02, Last modification date: 2023-12-27) |
Primary citation | Kopecky, D.J.,Hao, X.,Chen, Y.,Fu, J.,Jiao, X.,Jaen, J.C.,Cardozo, M.G.,Liu, J.,Wang, Z.,Walker, N.P.,Wesche, H.,Li, S.,Farrelly, E.,Xiao, S.H.,Kayser, F. Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorg.Med.Chem.Lett., 18:6352-6356, 2008 Cited by PubMed: 18993068DOI: 10.1016/j.bmcl.2008.10.092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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