3EQM

Crystal structure of human placental aromatase cytochrome P450 in complex with androstenedione

3EQM の概要

• エントリーDOI: 10.2210/pdb3eqm/pdb
• 分子名称: Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, 4-ANDROSTENE-3-17-DIONE, ... (5 entities in total)
• 機能のキーワード: human aromatase, cytochrome p450, membrane protein, microsomal, estrogen, biosynthesis of steroid hormone, disease mutation, heme, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Peripheral membrane protein: P11511
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59047.70

構造登録者

Ghosh, D. (登録日: 2008-10-01, 公開日: 2008-12-23, 最終更新日: 2024-02-21)

• 主引用文献: Ghosh, D.,Griswold, J.,Erman, M.,Pangborn, W.; Structural basis for androgen specificity and oestrogen synthesis in human aromatase.; Nature, 457:219-223, 2009; PubMed: 19129847; DOI: 10.1038/nature07614

実験手法

X-RAY DIFFRACTION (2.9 Å)