3ENS
Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate
3ENS の概要
エントリーDOI | 10.2210/pdb3ens/pdb |
分子名称 | Factor X light chain, Activated factor Xa heavy chain, GLYCEROL, ... (9 entities in total) |
機能のキーワード | serine protease, hydrolase, epidermal growth factor like domain, blood coagulation factor, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, blood clotting |
由来する生物種 | Homo sapiens (Human) 詳細 |
細胞内の位置 | Secreted: P00742 P00742 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 76475.27 |
構造登録者 | |
主引用文献 | Shi, Y.,Sitkoff, D.,Zhang, J.,Klei, H.E.,Kish, K.,Liu, E.C.,Hartl, K.S.,Seiler, S.M.,Chang, M.,Huang, C.,Youssef, S.,Steinbacher, T.E.,Schumacher, W.A.,Grazier, N.,Pudzianowski, A.,Apedo, A.,Discenza, L.,Yanchunas, J.,Stein, P.D.,Atwal, K.S. Design, Structure-Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors. J.Med.Chem., 51:7541-7551, 2008 Cited by PubMed: 18998662DOI: 10.1021/jm800855x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
構造検証レポート
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