3EMV

Crystal structure of Plasmodium vivax PNP with sulphate

Summary for 3EMV

Entry DOI	10.2210/pdb3emv/pdb
Related	3ENZ
Descriptor	Uridine phosphorylase, putative, SULFATE ION (3 entities in total)
Functional Keywords	transferase, binary complex, purine nucleoside phosphorylase, uridine phosphorylase, putative
Biological source	Plasmodium vivax
Total number of polymer chains	1
Total formula weight	28422.87
Authors	Chaikuad, A.,Brady, R.L. (deposition date: 2008-09-25, release date: 2009-08-04, Last modification date: 2023-11-01)
Primary citation	Chaikuad, A.,Brady, R.L. Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases Bmc Struct.Biol., 9:42-42, 2009 Cited by PubMed Abstract: Purine nucleoside phosphorylase (PNP) is central to purine salvage mechanisms in Plasmodium parasites, the causative agents of malaria. Most human malaria results from infection either by Plasmodium falciparum (Pf), the deadliest form of the parasite, or by the widespread Plasmodium vivax (Pv). Whereas the PNP enzyme from Pf has previously been studied in detail, despite the prevalence of Pv little is known about many of the key metabolic enzymes from this parasite, including PvPNP. PubMed: 19575810 DOI: 10.1186/1472-6807-9-42 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation