3EMV

Crystal structure of Plasmodium vivax PNP with sulphate

3EMV の概要

• エントリーDOI: 10.2210/pdb3emv/pdb
• 関連するPDBエントリー: 3ENZ
• 分子名称: Uridine phosphorylase, putative, SULFATE ION (3 entities in total)
• 機能のキーワード: transferase, binary complex, purine nucleoside phosphorylase, uridine phosphorylase, putative
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28422.87

構造登録者

Chaikuad, A.,Brady, R.L. (登録日: 2008-09-25, 公開日: 2009-08-04, 最終更新日: 2023-11-01)

主引用文献

Chaikuad, A.,Brady, R.L.
Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
Bmc Struct.Biol., 9:42-42, 2009

PubMed Abstract: Purine nucleoside phosphorylase (PNP) is central to purine salvage mechanisms in Plasmodium parasites, the causative agents of malaria. Most human malaria results from infection either by Plasmodium falciparum (Pf), the deadliest form of the parasite, or by the widespread Plasmodium vivax (Pv). Whereas the PNP enzyme from Pf has previously been studied in detail, despite the prevalence of Pv little is known about many of the key metabolic enzymes from this parasite, including PvPNP.

PubMed: 19575810
DOI: 10.1186/1472-6807-9-42

実験手法

X-RAY DIFFRACTION (1.85 Å)