3ELM
Crystal Structure of MMP-13 Complexed with Inhibitor 24f
Summary for 3ELM
Entry DOI | 10.2210/pdb3elm/pdb |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | metallo-enzyme, mmp-13, carboxylate inhibitor, calcium, collagen degradation, disease mutation, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 2 |
Total formula weight | 40034.20 |
Authors | Kulathila, R.,Monovich, L.,Koehn, J. (deposition date: 2008-09-22, release date: 2009-07-21, Last modification date: 2024-02-21) |
Primary citation | Monovich, L.G.,Tommasi, R.A.,Fujimoto, R.A.,Blancuzzi, V.,Clark, K.,Cornell, W.D.,Doti, R.,Doughty, J.,Fang, J.,Farley, D.,Fitt, J.,Ganu, V.,Goldberg, R.,Goldstein, R.,Lavoie, S.,Kulathila, R.,Macchia, W.,Parker, D.T.,Melton, R.,O'Byrne, E.,Pastor, G.,Pellas, T.,Quadros, E.,Reel, N.,Roland, D.M.,Sakane, Y.,Singh, H.,Skiles, J.,Somers, J.,Toscano, K.,Wigg, A.,Zhou, S.,Zhu, L.,Shieh, W.C.,Xue, S.,McQuire, L.W. Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13 J.Med.Chem., 52:3523-3538, 2009 Cited by PubMed: 19422229DOI: 10.1021/jm801394m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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