3ELM

Crystal Structure of MMP-13 Complexed with Inhibitor 24f

3ELM の概要

• エントリーDOI: 10.2210/pdb3elm/pdb
• 分子名称: Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: metallo-enzyme, mmp-13, carboxylate inhibitor, calcium, collagen degradation, disease mutation, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P45452
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40034.20

構造登録者

Kulathila, R.,Monovich, L.,Koehn, J. (登録日: 2008-09-22, 公開日: 2009-07-21, 最終更新日: 2024-02-21)

• 主引用文献: Monovich, L.G.,Tommasi, R.A.,Fujimoto, R.A.,Blancuzzi, V.,Clark, K.,Cornell, W.D.,Doti, R.,Doughty, J.,Fang, J.,Farley, D.,Fitt, J.,Ganu, V.,Goldberg, R.,Goldstein, R.,Lavoie, S.,Kulathila, R.,Macchia, W.,Parker, D.T.,Melton, R.,O'Byrne, E.,Pastor, G.,Pellas, T.,Quadros, E.,Reel, N.,Roland, D.M.,Sakane, Y.,Singh, H.,Skiles, J.,Somers, J.,Toscano, K.,Wigg, A.,Zhou, S.,Zhu, L.,Shieh, W.C.,Xue, S.,McQuire, L.W.; Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13; J.Med.Chem., 52:3523-3538, 2009; PubMed: 19422229; DOI: 10.1021/jm801394m

実験手法

X-RAY DIFFRACTION (1.9 Å)