3EKC

structure of W60V beta-2 microglobulin mutant

Summary for 3EKC

• Entry DOI: 10.2210/pdb3ekc/pdb
• Related: 2Z9T
• Descriptor: Beta-2-microglobulin (2 entities in total)
• Functional Keywords: beta-2-microglobulin, tryptophan, glycine, amyloidosis, dra, beta fibrils, disease mutation, glycation, glycoprotein, immune response, immunoglobulin domain, mhc i, pyrrolidone carboxylic acid, secreted, immune system
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P61769
• Total number of polymer chains: 1
• Total formula weight: 11792.28

Authors

Ricagno, S.,Sangiovanni, E.,Bellotti, V.,Bolognesi, M. (deposition date: 2008-09-19, release date: 2009-05-26, Last modification date: 2023-11-01)

• Primary citation: Ricagno, S.,Raimondi, S.,Giorgetti, S.,Bellotti, V.,Bolognesi, M.; Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation; Biochem.Biophys.Res.Commun., 380:543-547, 2009; PubMed: 19284997; DOI: 10.1016/j.bbrc.2009.01.116

Experimental method

X-RAY DIFFRACTION (1.8 Å)