3EE8

Structure of NS1 effector domain

3EE8 の概要

• エントリーDOI: 10.2210/pdb3ee8/pdb
• 関連するPDBエントリー: 3EE9
• 分子名称: Non-structural protein 1 (2 entities in total)
• 機能のキーワード: zinc finger receptor, alternative splicing, cytoplasm, host-virus interaction, interferon antiviral system evasion, nucleus, rna-binding, suppressor of rna silencing, viral protein
• 由来する生物種: Influenza A virus (A/Udorn/307/1972(H3N2))
• 細胞内の位置: Host nucleus : P03495
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27591.98

構造登録者

Xia, S.,Monzingo, A.F.,Robertus, J.D. (登録日: 2008-09-04, 公開日: 2009-01-13, 最終更新日: 2023-08-30)

主引用文献

Xia, S.,Monzingo, A.F.,Robertus, J.D.
Structure of NS1A effector domain from the influenza A/Udorn/72 virus.
Acta Crystallogr.,Sect.D, 65:11-17, 2009

PubMed Abstract: The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented.

PubMed: 19153461
DOI: 10.1107/S0907444908032186

実験手法

X-RAY DIFFRACTION (2.6 Å)