3E6I

Human cytochrome P450 2E1 in complex with the inhibitor indazole

3E6I の概要

• エントリーDOI: 10.2210/pdb3e6i/pdb
• 分子名称: Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE, 1H-indazole, ... (4 entities in total)
• 機能のキーワード: cyp2e1, p450 2e1, monooxygenase, acetaminophen, oxidoreductase, heme, endoplasmic reticulum, iron, membrane, metal-binding, microsome
• 由来する生物種: Homo sapiens
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P05181
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 111586.22

構造登録者

Porubsky, P.R.,Meneely, K.M.,Scott, E.E. (登録日: 2008-08-15, 公開日: 2008-09-23, 最終更新日: 2023-08-30)

• 主引用文献: Porubsky, P.R.,Meneely, K.M.,Scott, E.E.; Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.; J.Biol.Chem., 283:33698-33707, 2008; PubMed: 18818195; DOI: 10.1074/jbc.M805999200

実験手法

X-RAY DIFFRACTION (2.2 Å)