3E65

Murine INOS dimer with HEME, pterin and inhibitor AR-C120011

3E65 の概要

• エントリーDOI: 10.2210/pdb3e65/pdb
• 分子名称: Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total)
• 機能のキーワード: dimer, inducible nitric oxide synthase, calmodulin-binding, fad, fmn, heme, iron, metal-binding, nadp, oxidoreductase, polymorphism, zinc
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102692.21

構造登録者

Rosenfeld, R.J.,Garcin, E.D.,Getzoff, E.D. (登録日: 2008-08-14, 公開日: 2008-10-07, 最終更新日: 2023-08-30)

• 主引用文献: Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D.; Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.; Nat.Chem.Biol., 4:700-707, 2008; PubMed: 18849972; DOI: 10.1038/nchembio.115

実験手法

X-RAY DIFFRACTION (2.05 Å)