3E1X

The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution

3E1X の概要

• エントリーDOI: 10.2210/pdb3e1x/pdb
• 関連するPDBエントリー: 1EON 1EOP 3E16
• 分子名称: Prostasin, GLYCEROL (3 entities in total)
• 機能のキーワード: prostasin, enac, hcap-1, channel activating protease, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, transmembrane, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Prostasin heavy chain: Secreted, extracellular space: Q16651
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29792.19

構造登録者

Spraggon, G.,Hornsby, M.,Shipway, A.,Harris, J.L.,Lesley, S.A. (登録日: 2008-08-04, 公開日: 2009-05-05, 最終更新日: 2023-08-30)

• 主引用文献: Spraggon, G.,Hornsby, M.,Shipway, A.,Tully, D.C.,Bursulaya, B.,Danahay, H.,Harris, J.L.,Lesley, S.A.; Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.; Protein Sci., 18:1081-1094, 2009; PubMed: 19388054; DOI: 10.1002/pro.118

実験手法

X-RAY DIFFRACTION (1.7 Å)