3E0B
Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
Summary for 3E0B
| Entry DOI | 10.2210/pdb3e0b/pdb |
| Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, ... (4 entities in total) |
| Functional Keywords | oxidoreductase |
| Biological source | Bacillus anthracis |
| Total number of polymer chains | 2 |
| Total formula weight | 41606.53 |
| Authors | Anderson, A.C.,Beierlein, J.M.,Frey, K.M. (deposition date: 2008-07-31, release date: 2008-11-25, Last modification date: 2023-11-01) |
| Primary citation | Beierlein, J.M.,Frey, K.M.,Bolstad, D.B.,Pelphrey, P.M.,Joska, T.M.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase J.Med.Chem., 51:7532-7540, 2008 Cited by PubMed: 19007108DOI: 10.1021/jm800776a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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