3E01

HIV-RT with non-nucleoside inhibitor annulated pyrazole 2

3E01 の概要

• エントリーDOI: 10.2210/pdb3e01/pdb
• 関連するPDBエントリー: 3DYA
• 分子名称: Gag-Pol polyprotein, 3-[2-bromo-4-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-methylbenzonitrile (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116529.43

構造登録者

Harris, S.F.,Villasenor, A. (登録日: 2008-07-30, 公開日: 2008-11-25, 最終更新日: 2024-02-21)

• 主引用文献: Sweeney, Z.K.,Harris, S.F.,Arora, S.F.,Javanbakht, H.,Li, Y.,Fretland, J.,Davidson, J.P.,Billedeau, J.R.,Gleason, S.K.,Hirschfeld, D.,Kennedy-Smith, J.J.,Mirzadegan, T.,Roetz, R.,Smith, M.,Sperry, S.,Suh, J.M.,Wu, J.,Tsing, S.,Villasenor, A.G.,Paul, A.,Su, G.,Heilek, G.,Hang, J.Q.,Zhou, A.S.,Jernelius, J.A.,Zhang, F.J.,Klumpp, K.; Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase; J.Med.Chem., 51:7449-7458, 2008; PubMed: 19007201; DOI: 10.1021/jm800527x

実験手法

X-RAY DIFFRACTION (2.95 Å)