3DZ7

Human AdoMetDC with 5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine

3DZ7 の概要

• エントリーDOI: 10.2210/pdb3dz7/pdb
• 関連するPDBエントリー: 1I72 1I79 1I7B 1I7C 1I7M 1JEN 3DZ2 3DZ3 3DZ4 3DZ5 3DZ6
• 分子名称: S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ... (5 entities in total)
• 機能のキーワード: complexes of adometdc with 8-substituted ligands, decarboxylase, lyase, pyruvate, s-adenosyl-l-methionine, spermidine biosynthesis, zymogen, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38820.08

構造登録者

Bale, S.,McCloskey, D.E.,Pegg, A.E.,Secrist III, J.A.,Guida, W.C.,Ealick, S.E. (登録日: 2008-07-29, 公開日: 2009-03-10, 最終更新日: 2023-11-15)

• 主引用文献: McCloskey, D.E.,Bale, S.,Secrist III, J.A.,Tiwari, A.,Moss III, T.H.,Valiyaveettil, J.,Brooks, W.H.,Guida, W.C.,Pegg, A.E.,Ealick, S.E.; New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine; J.Med.Chem., 52:1388-1407, 2009; PubMed: 19209891; DOI: 10.1021/jm801126a

実験手法

X-RAY DIFFRACTION (1.91 Å)