3DRU

Crystal Structure of Gly117Phe Alpha1-Antitrypsin

3DRU の概要

• エントリーDOI: 10.2210/pdb3dru/pdb
• 関連するPDBエントリー: 3DRM
• 分子名称: Alpha-1-antitrypsin (1 entity in total)
• 機能のキーワード: serpin, serine proteinase inhibitor, alpha1-antitrypsin, polymerisation, rational drug design, conformational disease, emphysema, cirrhosis, acute phase, alternative splicing, blood coagulation, disease mutation, glycoprotein, hydrolase, polymorphism, protease, protease inhibitor, secreted, serine protease inhibitor, hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 137105.60

構造登録者

Gooptu, B.,Nobeli, I.,Purkiss, A.,Phillips, R.L.,Mallya, M.,Lomas, D.A.,Barrett, T.E. (登録日: 2008-07-11, 公開日: 2009-03-31, 最終更新日: 2024-02-21)

• 主引用文献: Gooptu, B.,Miranda, E.,Nobeli, I.,Mallya, M.,Purkiss, A.,Brown, S.C.,Summers, C.,Phillips, R.L.,Lomas, D.A.,Barrett, T.E.; Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design.; J.Mol.Biol., 387:857-868, 2009; PubMed: 19232354; DOI: 10.1016/j.jmb.2009.01.069

実験手法

X-RAY DIFFRACTION (3.2 Å)