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3DQT

Structure of endothelial NOS heme domain in complex with a inhibitor (+-)-N1-{trans-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-chlorobenzyl)ethane-1,2-diamine

Summary for 3DQT
Entry DOI10.2210/pdb3dqt/pdb
Related3B3P 3DQS
DescriptorNitric oxide synthase, endothelial, CACODYLATE ION, ACETATE ION, ... (9 entities in total)
Functional Keywordsnitric oxide synthase heme enzyme inhibitor, blood coagulation, calmodulin-binding, cytoskeleton, fad, fmn, golgi apparatus, heme, iron, lipoprotein, membrane, metal-binding, myristate, nadp, oxidoreductase, palmitate, phosphoprotein
Biological sourceBos taurus (Bovine)
Cellular locationCell membrane: P29473
Total number of polymer chains2
Total formula weight96813.03
Authors
Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2008-07-09, release date: 2009-03-31, Last modification date: 2024-02-21)
Primary citationIgarashi, J.,Li, H.,Jamal, J.,Ji, H.,Fang, J.,Lawton, G.R.,Silverman, R.B.,Poulos, T.L.
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52:2060-2066, 2009
Cited by
PubMed: 19296678
DOI: 10.1021/jm900007a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.54 Å)
Structure validation

217705

数据于2024-03-27公开中

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