3DQR

Structure of neuronal NOS D597N/M336V mutant heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine

Summary for 3DQR

Entry DOI	10.2210/pdb3dqr/pdb
Related	3B3N 3DQS 3DQT
Descriptor	Nitric oxide synthase, brain, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	nitric oxide synthase heme enzyme inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, heme, iron, membrane, metal-binding, nadp, oxidoreductase
Biological source	Rattus norvegicus (Rat)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains	2
Total formula weight	99928.58
Authors	Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2008-07-09, release date: 2009-03-31, Last modification date: 2024-02-21)
Primary citation	Igarashi, J.,Li, H.,Jamal, J.,Ji, H.,Fang, J.,Lawton, G.R.,Silverman, R.B.,Poulos, T.L. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. J.Med.Chem., 52:2060-2066, 2009 Cited by PubMed: 19296678 DOI: 10.1021/jm900007a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation