3DQR
Structure of neuronal NOS D597N/M336V mutant heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine
Summary for 3DQR
Entry DOI | 10.2210/pdb3dqr/pdb |
Related | 3B3N 3DQS 3DQT |
Descriptor | Nitric oxide synthase, brain, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase heme enzyme inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, heme, iron, membrane, metal-binding, nadp, oxidoreductase |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476 |
Total number of polymer chains | 2 |
Total formula weight | 99928.58 |
Authors | Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2008-07-09, release date: 2009-03-31, Last modification date: 2024-02-21) |
Primary citation | Igarashi, J.,Li, H.,Jamal, J.,Ji, H.,Fang, J.,Lawton, G.R.,Silverman, R.B.,Poulos, T.L. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. J.Med.Chem., 52:2060-2066, 2009 Cited by PubMed: 19296678DOI: 10.1021/jm900007a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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