3DQR

Structure of neuronal NOS D597N/M336V mutant heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine

3DQR の概要

• エントリーDOI: 10.2210/pdb3dqr/pdb
• 関連するPDBエントリー: 3B3N 3DQS 3DQT
• 分子名称: Nitric oxide synthase, brain, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase heme enzyme inhibitor, alternative splicing, calmodulin-binding, cell projection, fad, fmn, heme, iron, membrane, metal-binding, nadp, oxidoreductase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99928.58

構造登録者

Igarashi, J.,Li, H.,Poulos, T.L. (登録日: 2008-07-09, 公開日: 2009-03-31, 最終更新日: 2024-02-21)

• 主引用文献: Igarashi, J.,Li, H.,Jamal, J.,Ji, H.,Fang, J.,Lawton, G.R.,Silverman, R.B.,Poulos, T.L.; Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.; J.Med.Chem., 52:2060-2066, 2009; PubMed: 19296678; DOI: 10.1021/jm900007a

実験手法

X-RAY DIFFRACTION (2.4 Å)