3DOZ

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with compound 3k

3DOZ の概要

• エントリーDOI: 10.2210/pdb3doz/pdb
• 関連するPDBエントリー: 2GLL 3DOY 3DP0 3DP1 3DP2 3DP3
• 分子名称: (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... (5 entities in total)
• 機能のキーワード: fabz complex, lyase
• 由来する生物種: Helicobacter pylori (Campylobacter pylori)
• 細胞内の位置: Cytoplasm (By similarity): Q5G940
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 111156.23

構造登録者

Zhang, L.,He, L.,Liu, X.,Liu, H.,Shen, X.,Jiang, H. (登録日: 2008-07-07, 公開日: 2009-05-05, 最終更新日: 2023-11-01)

• 主引用文献: He, L.,Zhang, L.,Liu, X.,Li, X.,Zheng, M.,Li, H.,Yu, K.,Chen, K.,Shen, X.,Jiang, H.,Liu, H.; Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.; J.Med.Chem., 52:2465-2481, 2009; PubMed: 19309082; DOI: 10.1021/jm8015602

実験手法

X-RAY DIFFRACTION (2.5 Å)