3DM1

Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide

3DM1 の概要

• エントリーDOI: 10.2210/pdb3dm1/pdb
• 分子名称: Chromobox protein homolog 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (3 entities in total)
• 機能のキーワード: chromobox homolog 3, structural genomics, structural genomics consortium, sgc, chromatin regulator, nucleus, phosphoprotein, repressor, transcription, transcription regulation
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Nucleus : Q13185 Q96KQ7
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 33198.05

構造登録者

Amaya, M.F.,Ravichandran, M.,Loppnau, P.,Kozieradzki, I.,Edwards, A.M.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Bochkarev, A.,Min, J.,Ouyang, H.,Structural Genomics Consortium (SGC) (登録日: 2008-06-30, 公開日: 2008-08-19, 最終更新日: 2025-03-26)

主引用文献

Ruan, J.,Ouyang, H.,Amaya, M.F.,Ravichandran, M.,Loppnau, P.,Min, J.,Zang, J.
Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a.
Plos One, 7:e35376-e35376, 2012

PubMed Abstract: HP1 proteins are highly conserved heterochromatin proteins, which have been identified to be structural adapters assembling a variety of macromolecular complexes involved in regulation of gene expression, chromatin remodeling and heterochromatin formation. Much evidence shows that HP1 proteins interact with numerous proteins including methylated histones, histone methyltransferases and so on. Cbx3 is one of the paralogues of HP1 proteins, which has been reported to specifically recognize trimethylated histone H3K9 mark, and a consensus binding motif has been defined for the Cbx3 chromodomain.

PubMed: 22514736
DOI: 10.1371/journal.pone.0035376

実験手法

X-RAY DIFFRACTION (2.4 Å)