3DLE

Crystal structure of hiv-1 reverse transcriptase in complex with GF128590.

3DLE の概要

• エントリーDOI: 10.2210/pdb3dle/pdb
• 関連するPDBエントリー: 3DLG
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, 2-[4-chloro-2-(phenylcarbonyl)phenoxy]-N-phenylacetamide, ... (4 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, aids, nnrti, gf128590, drug resistance, hydrolase, transferase
• 由来する生物種: HIV-1 M:B_HXB2R (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116359.81

構造登録者

Ren, J.,Chamberlain, P.P.,Stammers, D.K. (登録日: 2008-06-27, 公開日: 2008-08-12, 最終更新日: 2011-07-13)

• 主引用文献: Ren, J.,Chamberlain, P.P.,Stamp, A.,Short, S.A.,Weaver, K.L.,Romines, K.R.,Hazen, R.,Freeman, A.,Ferris, R.G.,Andrews, C.W.,Boone, L.,Chan, J.H.,Stammers, D.K.; Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.; J.Med.Chem., 51:5000-5008, 2008; PubMed: 18665583; DOI: 10.1021/jm8004493

実験手法

X-RAY DIFFRACTION (2.5 Å)