3DEZ

Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans

3DEZ の概要

• エントリーDOI: 10.2210/pdb3dez/pdb
• 分子名称: Orotate phosphoribosyltransferase, SULFATE ION (3 entities in total)
• 機能のキーワード: orotate phosphoribosyltransferase, glycosyltransferase, magnesium, pyrimidine biosynthesis, transferase
• 由来する生物種: Streptococcus mutans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53106.43

構造登録者

Liu, C.P.,Gao, Z.Q.,Hou, H.F.,Li, L.F.,Su, X.D.,Dong, Y.H. (登録日: 2008-06-11, 公開日: 2009-06-16, 最終更新日: 2023-11-01)

主引用文献

Liu, C.P.,Xu, R.,Gao, Z.Q.,Xu, J.H.,Hou, H.F.,Li, L.Q.,She, Z.,Li, L.F.,Su, X.D.,Liu, P.,Dong, Y.H.
Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans
Acta Crystallogr.,Sect.F, 66:498-502, 2010

PubMed Abstract: Orotate phosphoribosyltransferase (OPRTase) catalyzes the OMP-forming step in de novo pyrimidine-nucleotide biosynthesis. Here, the crystal structure of OPRTase from the caries pathogen Streptococcus mutans is reported at 2.4 A resolution. S. mutans OPRTase forms a symmetric dimer and each monomer binds two sulfates at the active sites. The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism.

PubMed: 20445243
DOI: 10.1107/S1744309110009243

実験手法

X-RAY DIFFRACTION (2.4 Å)