3DEK
Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors
Summary for 3DEK
Entry DOI | 10.2210/pdb3dek/pdb |
Related | 3DEH 3DEI 3DEJ |
Descriptor | Caspase-3, N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide (3 entities in total) |
Functional Keywords | caspase-3, isoquinoline-1, 3, 4-trione derivatives, inactivation, protein-inhibitor complex, apoptosis, cytoplasm, hydrolase, phosphoprotein, polymorphism, protease, s-nitrosylation, thiol protease, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P42574 |
Total number of polymer chains | 4 |
Total formula weight | 114693.38 |
Authors | |
Primary citation | Du, J.-Q.,Wu, J.,Zhang, H.-J.,Zhang, Y.-H.,Qiu, B.-Y.,Wu, F.,Chen, Y.-H.,Li, J.-Y.,Nan, F.-J.,Ding, J.-P.,Li, J. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283:30205-30215, 2008 Cited by PubMed: 18768468DOI: 10.1074/jbc.M803347200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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