3DEE

CRYSTAL STRUCTURE OF A PUTATIVE REGULATORY PROTEIN INVOLVED IN TRANSCRIPTION (NGO1945) FROM NEISSERIA GONORRHOEAE FA 1090 AT 2.25 A RESOLUTION

3DEE の概要

• エントリーDOI: 10.2210/pdb3dee/pdb
• 分子名称: Putative regulatory protein, CHLORIDE ION, IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: putative regulatory protein, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, transcription
• 由来する生物種: Neisseria gonorrhoeae FA 1090
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29145.34

構造登録者

Joint Center for Structural Genomics (JCSG) (登録日: 2008-06-09, 公開日: 2008-08-05, 最終更新日: 2024-10-09)

主引用文献

Das, D.,Grishin, N.V.,Kumar, A.,Carlton, D.,Bakolitsa, C.,Miller, M.D.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Burra, P.,Chen, C.,Chiu, H.J.,Chiu, M.,Clayton, T.,Deller, M.C.,Duan, L.,Ellrott, K.,Ernst, D.,Farr, C.L.,Feuerhelm, J.,Grzechnik, A.,Grzechnik, S.K.,Grant, J.C.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Johnson, H.A.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Krishna, S.S.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Oommachen, S.,Paulsen, J.,Puckett, C.,Reyes, R.,Rife, C.L.,Sefcovic, N.,Tien, H.J.,Trame, C.B.,van den Bedem, H.,Weekes, D.,Wooten, T.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.
Acta Crystallogr.,Sect.F, 66:1174-1181, 2010

PubMed Abstract: Proteins with the DUF2063 domain constitute a new Pfam family, PF09836. The crystal structure of a member of this family, NGO1945 from Neisseria gonorrhoeae, has been determined and reveals that the N-terminal DUF2063 domain is likely to be a DNA-binding domain. In conjunction with the rest of the protein, NGO1945 is likely to be involved in transcriptional regulation, which is consistent with genomic neighborhood analysis. Of the 216 currently known proteins that contain a DUF2063 domain, the most significant sequence homologs of NGO1945 (∼40-99% sequence identity) are from various Neisseria and Haemophilus species. As these are important human pathogens, NGO1945 represents an interesting candidate for further exploration via biochemical studies and possible therapeutic intervention.

PubMed: 20944208
DOI: 10.1107/S1744309109022672

実験手法

X-RAY DIFFRACTION (2.1 Å)