3DD0

Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

3DD0 の概要

関連するPDBエントリー3D8W 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW
分子名称Carbonic anhydrase 2, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ... (4 entities in total)
機能のキーワードcarbonic anhydrase ii complex, caix mimic inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm P00918
ポリマー鎖数1
分子量合計29612.79
構造登録者
Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (登録日: 2008-06-04, 公開日: 2009-03-03, 最終更新日: 2011-07-13)
主引用文献
Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R.
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48:1322-1331, 2009
PubMed: 19170619 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi802035f
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.48 Å)
?

構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers401.8%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード