3DCS

Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

3DCS の概要

• エントリーDOI: 10.2210/pdb3dcs/pdb
• 関連するPDBエントリー: 3D8W 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCW 3DD0
• 分子名称: Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase ii complex, caix mimic inhibitors, disease mutation, lyase, metal-binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29620.77

構造登録者

Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (登録日: 2008-06-04, 公開日: 2009-03-03, 最終更新日: 2023-08-30)

• 主引用文献: Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R.; Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties; Biochemistry, 48:1322-1331, 2009; PubMed: 19170619; DOI: 10.1021/bi802035f

実験手法

X-RAY DIFFRACTION (1.8 Å)