3DC9
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Summary for 3DC9
Entry DOI | 10.2210/pdb3dc9/pdb |
Related | 3D8W 3D9Z 3DAZ 3DBU 3DC3 3DCC |
Descriptor | Carbonic anhydrase 2, ZINC ION (3 entities in total) |
Functional Keywords | carbonic anhydrase ii complex, caix mimic inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29384.49 |
Authors | Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (deposition date: 2008-06-03, release date: 2009-03-03, Last modification date: 2023-08-30) |
Primary citation | Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48:1322-1331, 2009 Cited by PubMed: 19170619DOI: 10.1021/bi802035f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)