3DB3
Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1 in complex with trimethylated histone H3-K9 peptide
Summary for 3DB3
Entry DOI | 10.2210/pdb3db3/pdb |
Related | 2FAZ 3BI7 3CLZ 3DB4 |
Descriptor | E3 ubiquitin-protein ligase UHRF1, Trimethylated histone H3-K9 peptide (3 entities in total) |
Functional Keywords | cell cycle, dna damage, dna repair, tandem tudor domains, ligase, metal binding, dna replication, transcriptional silencing, chromatin, phosphorylation, transcription, transcription regulation, ubl conjugation pathway, zinc-finger, structural genomics, structural genomics consortium, sgc, dna-binding, metal-binding, nucleus, phosphoprotein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q96T88 Q71DI3 |
Total number of polymer chains | 2 |
Total formula weight | 19718.38 |
Authors | Walker, J.R.,Avvakumov, G.V.,Xue, S.,Dong, A.,Li, Y.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-05-30, release date: 2008-09-16, Last modification date: 2012-04-18) |
Primary citation | Nady, N.,Lemak, A.,Walker, J.R.,Avvakumov, G.V.,Kareta, M.S.,Achour, M.,Xue, S.,Duan, S.,Allali-Hassani, A.,Zuo, X.,Wang, Y.X.,Bronner, C.,Chedin, F.,Arrowsmith, C.H.,Dhe-Paganon, S. Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J.Biol.Chem., 286:24300-24311, 2011 Cited by PubMed: 21489993DOI: 10.1074/jbc.M111.234104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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