3D90

Crystal structure of the human progesterone receptor ligand-binding domain bound to levonorgestrel

3D90 の概要

• エントリーDOI: 10.2210/pdb3d90/pdb
• 分子名称: Progesterone receptor, 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE (3 entities in total)
• 機能のキーワード: progesterone receptor, steroid receptor, nuclear receptor, transcription factor, women health, contraception, alternative splicing, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, steroid-binding, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus. Isoform A: Nucleus: P06401
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60102.54

構造登録者

Petit-Topin, I.,Turque, N.,Ulman, A.,Gainer, E.,Rafestin-Oblin, M.E.,Fagart, J. (登録日: 2008-05-26, 公開日: 2009-05-26, 最終更新日: 2023-11-01)

• 主引用文献: Petit-Topin, I.,Turque, N.,Fagart, J.,Fay, M.,Ulmann, A.,Gainer, E.,Rafestin-Oblin, M.E.; Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins; Mol.Pharmacol., 75:1317-1324, 2009; PubMed: 19289570; DOI: 10.1124/mol.108.054312

実験手法

X-RAY DIFFRACTION (2.26 Å)