3D8W
Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Summary for 3D8W
Entry DOI | 10.2210/pdb3d8w/pdb |
Descriptor | Carbonic anhydrase II, ZINC ION, 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase ii, anti-cancer, benzolamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29674.84 |
Authors | Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (deposition date: 2008-05-26, release date: 2009-03-03, Last modification date: 2023-08-30) |
Primary citation | Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48:1322-1331, 2009 Cited by PubMed: 19170619DOI: 10.1021/bi802035f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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