3D8W

Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

3D8W の概要

• エントリーDOI: 10.2210/pdb3d8w/pdb
• 分子名称: Carbonic anhydrase II, ZINC ION, 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase ii, anti-cancer, benzolamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29674.84

構造登録者

Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (登録日: 2008-05-26, 公開日: 2009-03-03, 最終更新日: 2023-08-30)

• 主引用文献: Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R.; Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties; Biochemistry, 48:1322-1331, 2009; PubMed: 19170619; DOI: 10.1021/bi802035f

実験手法

X-RAY DIFFRACTION (1.7 Å)